BPC-157 and TB-500
This is a blend (10mg) each of BPC-157 (5mg) and TB-500 (5mg).
BPC-157 (short for Body Protection Compound-157) is a synthetic peptide derived from a protective protein found in gastric juice. First isolated in the 1990s, this partial sequence of body protection compound consists of 15 amino acids arranged in a specific sequence that appears to contribute to its biological activity. Its structure enables stability in gastric acid, unlike many other peptides that degrade in acidic environments. This unique property may contribute to its diverse effects across multiple tissue types.
TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4 (Tβ4), which is found in nearly all mammalian cells. The synthetic TB-500 represents the active segment of Tβ4, focusing on a specific portion believed to drive its biological activity.
While both peptides have been studied for tissue-regenerative properties, they appear to function through different mechanisms:
- BPC-157 may work primarily through growth factor-mediated pathways and nitric oxide systems.
- TB-500 appears to function mainly through actin-binding and subsequent cellular organization.
This mechanistic difference suggests they may have complementary effects when studied in laboratory settings, potentially affecting different aspects of the tissue repair process.
Lyophilized Peptides:
These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage. We do not use any fillers in this process.
Product Usage:
This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
TB-500 and BPC-157 Research
The potential synergistic effects of TB-500 and BPC-157 can be theorized based on their overlapping mechanisms in tissue repair, angiogenesis, and anti-inflammatory responses, as suggested by individual preclinical studies.
TB-500 primarily promotes cell migration, angiogenesis, and tissue regeneration by upregulating actin dynamics and modulating inflammation1. BPC-157, for its part, enhances wound healing, angiogenesis, and tissue repair through its effects on nitric oxide pathways, vascular endothelial growth factor (VEGF), and anti-inflammatory mechanisms2.
Both peptides share overlapping potential in promoting angiogenesis and reducing inflammation, which could amplify healing processes when combined. TB-500’s ability to stimulate endothelial cell migration may complement BPC-157’s role in stabilizing blood vessels and promoting microvascular growth. Their combined anti-inflammatory actions may also create a more favorable environment for tissue repair.
Although direct studies on their combined use are limited, their individual mechanisms suggest a strong theoretical basis for synergistic effects in tissue regeneration and recovery.
References
- Su, L., Kong, X., Loo, S., Gao, Y., Liu, B., Su, X., Dalan, R., Ma, J., & Ye, L. (2022). Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells. Stem cell research & therapy, 13(1), 13. https://doi.org/10.1186/s13287-021-02687-x.
- Seiwerth, S., Milavic, M., Vukojevic, J., Gojkovic, S., Krezic, I., Vuletic, L. B., Pavlov, K. H., Petrovic, A., Sikiric, S., Vranes, H., Prtoric, A., Zizek, H., Durasin, T., Dobric, I., Staresinic, M., Strbe, S., Knezevic, M., Sola, M., Kokot, A., Sever, M., … Sikiric, P. (2021). Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Frontiers in pharmacology, 12, 627533. https://doi.org/10.3389/fphar.2021.627533.
